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12 Nov, 26
AHA 2026
The AHA highlights focus on risk-guided intensive BP control, novel aldosterone synthase inhibitors, GLP-1RA–mediated BP reduction, digital BP management, and real-world combination therapy outcomes.
12 Nov, 26
The 2025 WHO guidelines recommend a stepwise, evidence-based infertility approach using lifestyle optimization, accurate diagnosis, letrozole first-line, and IVF escalation.
9 Nov, 26BMC Infect. Dis.
- Meta-analysis of 99 cohort studies found poor glycemic control significantly reduced treatment success (adjusted OR 0.22) & sputum conversion (adjusted OR 0.28).
- Poor glycemic control was associated with lower lesion resolution and cavity closure.
- Recurrence risk was nearly 5-fold higher with poor glycemic control; no significant differences were observed between FBG and HbA1c for short-term outcomes.
6 Nov, 26EP Europace.
- Among 2,712 Swiss-AF participants (mean age 73 yrs; 30.8% female), MRI-detected brain infarcts increased from 22.8% (AF-/HF-) to 44.6% (AF+/HF+), while white matter hyperintensities (WMH) increased from 43.2% to 65.6%
- AF & HF were independently associated with brain infarcts (AF: OR 1.78; HF: OR 1.32; both p<0.001) & WMH (AF: OR 1.71; HF: OR 1.45; both p<0.001), with no significant AF-HF interaction.
5 Nov, 26Diabetes Obes Metab.
- In a cohort of obesity-medication eligible adults without diabetes, 12 mo of persistent tirzepatide treatment produced clinically meaningful weight loss in both GLP-1 RA–naïve & experienced patients
- Mean weight reduction was 19.3% in GLP-1 RA–naïve patients & 13.1% in GLP-1 RA–experienced patients
- >85% had ≥1 obesity-related comorbidity at baseline, supporting effectiveness comparable to clinical trial outcomes.
3 Nov, 26Diabetic Med.
- This updated meta-analysis (25 studies; n=7,379) showed that preventive interventions initiated within 5 yrs after a GDM pregnancy reduced T2DM risk by 15% (RR 0.85; 95% CrI 0.69-1.04) & T2DM hazard by 32% (HR 0.68; 95% CrI 0.40-1.07), with high posterior probabilities (95%-96%)
- Improvements were also seen in FPG, BMI, HOMA-IR, & total cholesterol.
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12 Nov, 26
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